Sweet’s syndrome is a rare skin condition. Its main signs include fever and painful skin lesions that appear mostly on one’s arms, neck, head and trunk. The exact cause of sweet’s syndrome isn’t known. In some people, it’s triggered by an infection, illness or certain medications. Sweet’s syndrome can also occur with some types of cancer. The disorder occurs with other medical conditions like upper respiratory infections, pregnancy, or gastrointestinal infections. Certain medications can also trigger sweet syndrome. These include some antibiotics, like Bactrim, NSAIDS and granulocyte colony-stimulating factor (G-CSF), which stimulates one’s body to make neutrophils, a type of immune system cell. The major symptom of Sweet syndrome is the sudden onset of tender or painful bumps (nodules or papules) on the arms, legs, face or neck. They may also occur on the thighs and trunk. Papules are solid, raises lesions; nodules are slightly larger and may extend deeper into the skin. Drug-induced Sweet syndrome develops after using certain medications, the most commonly associated drug is known as granulocyte-colony stimulating factor. This drug is used to stimulate the production of neutrophils. A wide variety of additional drugs have been associated with Sweet syndrome, although less often. In general, women are more likely to have Sweet’s syndrome than are men.Though older adults and even infants can develop Sweet’s syndrome, the condition mainly affects people between the ages of 30 and 60. In some cases, Sweet syndrome affects other organ systems in the body, like one’s nervous and gastrointestinal systems. Most commonly, eye problems occur. These may include eye inflammation, increased eye pressure (glaucoma), and corneal ulceration, or sores on one’s cornea. Can Sweet syndrome be prevented? Because doctors don’t know what causes Sweet syndrome, it is not possible to prevent it. There are no prophylactic drugs or vaccines available to prevent Sweet syndrome. Treating underlying associations, such as malignancy and autoimmune diseases, may decrease recurrences. Sweet syndrome can go away by itself without treatment if it’s not caused by another health condition. But this could take weeks or months. Corticosteroid pills can help with redness, itching, swelling, and allergic reactions.